This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Bipolar Disorder Genetic?
- Heritability
- ~75%
- Inheritance
- multifactorial
- Key genes
- CACNA1C,ANK3,CLOCK,DGKH
CircleDNA's Premium Test includes personalised reports on Bipolar Disorder risk. See your genetic risk →
Bipolar disorder has one of the highest heritabilities of any psychiatric condition. First-degree relatives have an 8–10 times higher risk than the general population.
How Genetic Is Bipolar Disorder?
Genetics plays a meaningful role in Bipolar Disorder, with heritability estimated at around 75%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Bipolar Disorder: CACNA1C,ANK3,CLOCK,DGKH. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Bipolar Disorder?
Family history does matter. Having close relatives with Bipolar Disorder can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →