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Is Club Foot Genetic?
- Heritability
- ~65%
- Inheritance
- multifactorial
- Key genes
- PITX1,TBX4,TPM1,MYH3
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Clubfoot (talipes equinovarus) has significant heritability. Having an affected sibling increases recurrence risk to approximately 3–5%.
How Genetic Is Club Foot?
Genetics plays a meaningful role in Club Foot, with heritability estimated at around 65%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Club Foot: PITX1,TBX4,TPM1,MYH3. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Club Foot?
Family history does matter. Having close relatives with Club Foot can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
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