This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Depression Genetic?
- Heritability
- ~37%
- Inheritance
- multifactorial
- Key genes
- SLC6A4,BDNF,FKBP5,CRHR1
CircleDNA's Premium Test includes personalised reports on Depression risk. See your genetic risk →
Major depressive disorder has a significant genetic component with heritability estimates around 37%. No single gene is responsible; many variants each contribute small effects.
How Genetic Is Depression?
Genetics plays a meaningful role in Depression, with heritability estimated at around 37%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Depression: SLC6A4,BDNF,FKBP5,CRHR1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: CDC Genomics
Does Family History Matter for Depression?
Family history does matter. Having close relatives with Depression can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →