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Is Gastric Cancer Genetic?
- Heritability
- ~25%
- Inheritance
- polygenic
- Key genes
- CDH1 BRCA2 MLH1
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Most stomach cancer is caused by H. pylori infection; hereditary diffuse gastric cancer caused by CDH1 mutations carries >70% lifetime risk.
How Genetic Is Gastric Cancer?
Gastric Cancer involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 25%, though no single gene determines outcome on its own.
Key genes associated with Gastric Cancer: CDH1 BRCA2 MLH1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Gastric Cancer?
Family history can be informative for Gastric Cancer, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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