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Is Glaucoma Genetic?
- Heritability
- ~60%
- Inheritance
- polygenic
- Key genes
- MYOC OPTN CYP1B1
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The leading cause of irreversible blindness worldwide. Family history is a major risk factor; multiple genes contribute to different subtypes.
How Genetic Is Glaucoma?
Glaucoma involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 60%, though no single gene determines outcome on its own.
Key genes associated with Glaucoma: MYOC OPTN CYP1B1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Glaucoma?
Family history can be informative for Glaucoma, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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