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Is Gorlin Syndrome Genetic?
Is Gorlin Syndrome hereditary? Here's what the research says about inherited risk.
- Heritability
- ~100%
- Inheritance
- autosomal-dominant
- Key genes
- PTCH1
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Gorlin syndrome (basal cell naevus syndrome) causes multiple basal cell carcinomas and jaw cysts as well as brain tumours and other abnormalities.
How Genetic Is Gorlin Syndrome?
Gorlin Syndrome has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Gorlin Syndrome: PTCH1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Gorlin Syndrome?
Yes — family history is one of the strongest predictors of Gorlin Syndrome. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
Frequently Asked Questions
Is Gorlin Syndrome genetic?
This condition has a strong genetic basis. Studies suggest heritability of approximately 100%. Key genes involved include PTCH1.
Can a DNA test reveal my risk of Gorlin Syndrome?
Yes — DNA tests such as CircleDNA's Premium Test include reports on Gorlin Syndrome risk based on your genetic variants.
Does family history matter for Gorlin Syndrome?
Yes — family history is one of the strongest predictors of Gorlin Syndrome. If a first-degree relative has been diagnosed, your own risk may be significantly elevated.
Is Gorlin Syndrome hereditary, meaning it's passed directly from parent to child?
Gorlin Syndrome follows a autosomal-dominant inheritance pattern in cases with a clear genetic cause, though not every case is inherited directly from a parent — some arise from new (de novo) mutations or a combination of genetic and environmental factors.
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- MedlinePlus Genetics
- MedlinePlus Genetics — National Library of Medicine
- CDC Genomics and Precision Health
Last updated: · Reviewed by the 247GeneticCheck editorial team
Content compiled with reference to peer-reviewed genetics literature and testing-provider documentation. This site does not provide medical or genetic counselling advice — always consult a healthcare professional or genetic counsellor before acting on DNA test results.
For nutritional data that may be relevant to managing Gorlin Syndrome, our calorie and nutrition checker covers thousands of foods. If you take medication alongside a genetic condition, check drug interaction guidance before combining supplements or treatments.