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Is Lactose Intolerance Genetic?
- Heritability
- ~90%
- Inheritance
- autosomal-recessive
- Key genes
- LCT
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Inability to digest lactose caused by variants in the LCT gene regulatory region affecting lactase persistence. Strongly hereditary.
How Genetic Is Lactose Intolerance?
Lactose Intolerance has a strong genetic basis. Research estimates heritability at approximately 90%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Lactose Intolerance: LCT. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Lactose Intolerance?
Yes — family history is one of the strongest predictors of Lactose Intolerance. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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