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Is Lung Cancer Genetic?
- Heritability
- ~18%
- Inheritance
- polygenic
- Key genes
- EGFR KRAS TP53
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Primarily caused by tobacco smoking; genetic factors including EGFR mutations and 15q25 variants influence risk and treatment response.
How Genetic Is Lung Cancer?
Lung Cancer involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 18%, though no single gene determines outcome on its own.
Key genes associated with Lung Cancer: EGFR KRAS TP53. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Lung Cancer?
Family history can be informative for Lung Cancer, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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