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Is Maturity-Onset Diabetes of the Young Genetic?
- Heritability
- ~95%
- Inheritance
- autosomal-dominant
- Key genes
- GCK,HNF1A,HNF4A
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MODY is a rare hereditary form of diabetes caused by single-gene mutations affecting insulin secretion. It affects fewer than 5% of people with diabetes.
How Genetic Is Maturity-Onset Diabetes of the Young?
Maturity-Onset Diabetes of the Young has a strong genetic basis. Research estimates heritability at approximately 95%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Maturity-Onset Diabetes of the Young: GCK,HNF1A,HNF4A. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Maturity-Onset Diabetes of the Young?
Yes — family history is one of the strongest predictors of Maturity-Onset Diabetes of the Young. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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