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Is Moyamoya Disease Genetic?
- Heritability
- ~10%
- Inheritance
- polygenic
- Key genes
- RNF213
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Progressive narrowing of brain arteries causing stroke; RNF213 variants are major risk factors in East Asian populations.
How Genetic Is Moyamoya Disease?
Moyamoya Disease involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 10%, though no single gene determines outcome on its own.
Key genes associated with Moyamoya Disease: RNF213. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Moyamoya Disease?
Family history can be informative for Moyamoya Disease, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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