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Is Polydactyly Genetic?
- Heritability
- ~70%
- Inheritance
- autosomal-dominant
- Key genes
- GLI3 SHH SALL4
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Extra digit(s) on hands or feet. Isolated polydactyly is often autosomal dominant with reduced penetrance; syndromic forms also exist.
How Genetic Is Polydactyly?
Genetics plays a meaningful role in Polydactyly, with heritability estimated at around 70%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Polydactyly: GLI3 SHH SALL4. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Polydactyly?
Family history does matter. Having close relatives with Polydactyly can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
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