This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Primary Sclerosing Cholangitis Genetic?
- Heritability
- ~50%
- Inheritance
- multifactorial
- Key genes
- HLA-DRB1,IL2,SH2B3
CircleDNA's Premium Test includes personalised reports on Primary Sclerosing Cholangitis risk. See your genetic risk →
Primary sclerosing cholangitis is a rare progressive liver disease causing inflammation and scarring of bile ducts. It has a moderate hereditary component.
How Genetic Is Primary Sclerosing Cholangitis?
Genetics plays a meaningful role in Primary Sclerosing Cholangitis, with heritability estimated at around 50%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Primary Sclerosing Cholangitis: HLA-DRB1,IL2,SH2B3. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Primary Sclerosing Cholangitis?
Family history does matter. Having close relatives with Primary Sclerosing Cholangitis can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →