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Is Psoriasis Genetic?
- Heritability
- ~65%
- Inheritance
- polygenic
- Key genes
- HLA-C IL12B IL23R
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An immune-mediated skin disease with heritability of ~65–70%. Over 50 genetic loci identified; HLA-C*06:02 is the strongest risk allele.
How Genetic Is Psoriasis?
Psoriasis involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 65%, though no single gene determines outcome on its own.
Key genes associated with Psoriasis: HLA-C IL12B IL23R. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Psoriasis?
Family history can be informative for Psoriasis, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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