This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Wilms Tumour Genetic?
- Heritability
- ~15%
- Inheritance
- multifactorial
- Key genes
- WT1,WTX,CTNNB1
CircleDNA's Premium Test includes personalised reports on Wilms Tumour risk. See your cancer genetic risk →
Wilms tumour is the most common kidney cancer in children. Approximately 1–2% of cases are hereditary with WT1 gene mutations being the most recognised cause.
How Genetic Is Wilms Tumour?
Genetics plays a meaningful role in Wilms Tumour, with heritability estimated at around 15%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Wilms Tumour: WT1,WTX,CTNNB1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Wilms Tumour?
Family history does matter. Having close relatives with Wilms Tumour can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →