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Is Antiphospholipid Syndrome Genetic?
- Heritability
- ~30%
- Inheritance
- polygenic
- Key genes
- HLA-DQ7 IRF5
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An autoimmune clotting disorder with modest heritability. HLA associations and complement genes contribute to genetic risk.
How Genetic Is Antiphospholipid Syndrome?
Antiphospholipid Syndrome involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 30%, though no single gene determines outcome on its own.
Key genes associated with Antiphospholipid Syndrome: HLA-DQ7 IRF5. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: CDC
Does Family History Matter for Antiphospholipid Syndrome?
Family history can be informative for Antiphospholipid Syndrome, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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