This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Idiopathic Pulmonary Fibrosis Genetic?
- Heritability
- ~55%
- Inheritance
- polygenic
- Key genes
- TERT TERC MUC5B
CircleDNA's Premium Test covers 500+ health and ancestry reports. Explore your DNA →
Progressive scarring lung disease with significant genetic component. MUC5B promoter variant is associated with common sporadic and familial IPF.
How Genetic Is Idiopathic Pulmonary Fibrosis?
Idiopathic Pulmonary Fibrosis involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 55%, though no single gene determines outcome on its own.
Key genes associated with Idiopathic Pulmonary Fibrosis: TERT TERC MUC5B. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Idiopathic Pulmonary Fibrosis?
Family history can be informative for Idiopathic Pulmonary Fibrosis, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →