This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Atrial Fibrillation Genetic?
- Heritability
- ~62%
- Inheritance
- polygenic
- Key genes
- PITX2 ZFHX3 SCN5A
CircleDNA's Premium Test includes personalised reports on Atrial Fibrillation risk. See your genetic risk →
The most common cardiac arrhythmia. Heritability studies suggest ~62% genetic contribution; over 100 risk loci have been identified.
How Genetic Is Atrial Fibrillation?
Atrial Fibrillation involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 62%, though no single gene determines outcome on its own.
Key genes associated with Atrial Fibrillation: PITX2 ZFHX3 SCN5A. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Atrial Fibrillation?
Family history can be informative for Atrial Fibrillation, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →