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Genetic Heart & Cardiovascular Conditions

Cardiovascular conditions where family history and inherited gene variants substantially affect your risk.

YES Is Arrhythmogenic Right Ventricular Cardiomyopathy genetic? ~90% heritable ARVC is an inherited heart muscle disease predisposing to ventricular arrhythmias and sudden cardiac… YES Is Brugada Syndrome genetic? ~70% heritable Brugada syndrome is an inherited arrhythmia disorder that increases the risk of sudden cardiac death… YES Is Cardiomyopathy genetic? ~50% heritable Cardiomyopathy refers to diseases of the heart muscle. Hypertrophic cardiomyopathy is one of the mos… YES Is Elevated Lipoprotein(a) genetic? ~90% heritable Lipoprotein(a) levels are almost entirely genetically determined with the LPA gene variants controll… YES Is Familial Hypercholesterolaemia genetic? ~90% heritable Familial hypercholesterolaemia causes very high LDL cholesterol from birth and dramatically increase… YES Is Hereditary Thrombophilia genetic? ~100% heritable Hereditary thrombophilias predispose to blood clots. Factor V Leiden and prothrombin G20210A mutatio… YES Is Hypertrophic Cardiomyopathy genetic? ~100% heritable The most common inherited heart disease (~1 in 500). Mutations in sarcomere proteins cause abnormal … YES Is Long QT Syndrome genetic? ~90% heritable Long QT syndrome is an inherited heart rhythm disorder that can cause fast and chaotic heartbeats an… YES Is Marfan Syndrome genetic? ~95% heritable Marfan syndrome is a connective tissue disorder caused by FBN1 mutations. It affects the heart, bloo… YES Is Monogenic Hypertension genetic? ~100% heritable Monogenic forms of hypertension caused by single gene mutations affecting aldosterone or cortisol pa… PARTIAL Is Aortic Aneurysm genetic? ~54% heritable Aortic aneurysm is an abnormal bulging of the aorta. Familial forms exist and several connective tis… PARTIAL Is Atrial Fibrillation genetic? ~62% heritable Atrial fibrillation is the most common cardiac arrhythmia. Genetic factors play a significant role p… PARTIAL Is Congenital Heart Defects genetic? ~30% heritable Congenital heart defects are the most common birth defects. Genetic factors account for 30–40% of ca… PARTIAL Is Dilated Cardiomyopathy genetic? ~48% heritable Dilated cardiomyopathy causes the heart to enlarge and pump poorly. Up to 48% of familial cases are … PARTIAL Is Heart Disease genetic? ~40% heritable Coronary heart disease is influenced by both genetic and lifestyle factors. Family history is one of… PARTIAL Is Hyperlipidaemia genetic? ~60% heritable Familial combined hyperlipidaemia is the most common hereditary lipid disorder. It raises both chole… PARTIAL Is Hypertension genetic? ~40% heritable High blood pressure affects around 1 in 3 adults. Genetic factors account for 30–50% of blood pressu… PARTIAL Is Hypertriglyceridaemia genetic? ~40% heritable Familial hypertriglyceridaemia causes elevated blood triglycerides and increases the risk of pancrea… PARTIAL Is Peripartum Cardiomyopathy genetic? ~20% heritable Peripartum cardiomyopathy occurs around childbirth and has a genetic predisposition in some cases. V… PARTIAL Is Peripheral Artery Disease genetic? ~36% heritable Peripheral artery disease involves narrowing of arteries supplying the legs. It shares many genetic … PARTIAL Is Pulmonary Arterial Hypertension genetic? ~70% heritable Familial pulmonary arterial hypertension is caused predominantly by BMPR2 mutations and causes high … PARTIAL Is Stroke genetic? ~37% heritable Stroke risk has a moderate genetic component. CADASIL caused by NOTCH3 mutations is the most common … COMPLEX Is Coronary Artery Disease genetic? ~56% heritable The leading cause of death worldwide. Heritability ~40–56%. Polygenic risk scores can identify indiv… COMPLEX Is Ischaemic Stroke genetic? ~38% heritable Family history is a significant risk factor. Heritability ~38%. Rare monogenic stroke syndromes (CAD… COMPLEX Is Mitral Valve Prolapse genetic? ~89% heritable The most common cardiac valvular abnormality (~2–3% prevalence). Twin studies show ~89% heritability… COMPLEX Is Sudden Cardiac Death genetic? ~45% heritable Genetic channelopathies and cardiomyopathies account for many cases of sudden cardiac arrest in youn…

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