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Is Dilated Cardiomyopathy Genetic?
- Heritability
- ~70%
- Inheritance
- autosomal-dominant
- Key genes
- TTN LMNA SCN5A
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Heart muscle disease causing dilation and systolic dysfunction. ~30–35% of cases are familial; TTN truncating variants are the most common cause.
How Genetic Is Dilated Cardiomyopathy?
Dilated Cardiomyopathy has a strong genetic basis. Research estimates heritability at approximately 70%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Dilated Cardiomyopathy: TTN LMNA SCN5A. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Dilated Cardiomyopathy?
Yes — family history is one of the strongest predictors of Dilated Cardiomyopathy. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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