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Is Arrhythmogenic Right Ventricular Cardiomyopathy Genetic?
Is Arrhythmogenic Right Ventricular Cardiomyopathy hereditary? Here's what the research says about inherited risk.
- Heritability
- ~90%
- Inheritance
- autosomal-dominant
- Key genes
- PKP2,DSP,DSG2,TMEM43
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ARVC is an inherited heart muscle disease predisposing to ventricular arrhythmias and sudden cardiac death. Autosomal dominant with incomplete penetrance.
How Genetic Is Arrhythmogenic Right Ventricular Cardiomyopathy?
Arrhythmogenic Right Ventricular Cardiomyopathy has a strong genetic basis. Research estimates heritability at approximately 90%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Arrhythmogenic Right Ventricular Cardiomyopathy: PKP2,DSP,DSG2,TMEM43. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Arrhythmogenic Right Ventricular Cardiomyopathy?
Yes — family history is one of the strongest predictors of Arrhythmogenic Right Ventricular Cardiomyopathy. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
Frequently Asked Questions
Is Arrhythmogenic Right Ventricular Cardiomyopathy genetic?
This condition has a strong genetic basis. Studies suggest heritability of approximately 90%. Key genes involved include PKP2,DSP,DSG2,TMEM43.
Can a DNA test reveal my risk of Arrhythmogenic Right Ventricular Cardiomyopathy?
Yes — DNA tests such as CircleDNA's Premium Test include reports on Arrhythmogenic Right Ventricular Cardiomyopathy risk based on your genetic variants.
Does family history matter for Arrhythmogenic Right Ventricular Cardiomyopathy?
Yes — family history is one of the strongest predictors of Arrhythmogenic Right Ventricular Cardiomyopathy. If a first-degree relative has been diagnosed, your own risk may be significantly elevated.
Is Arrhythmogenic Right Ventricular Cardiomyopathy hereditary, meaning it's passed directly from parent to child?
Arrhythmogenic Right Ventricular Cardiomyopathy follows a autosomal-dominant inheritance pattern in cases with a clear genetic cause, though not every case is inherited directly from a parent — some arise from new (de novo) mutations or a combination of genetic and environmental factors.
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- MedlinePlus Genetics
- MedlinePlus Genetics — National Library of Medicine
- CDC Genomics and Precision Health
Last updated: · Reviewed by the 247GeneticCheck editorial team
Content compiled with reference to peer-reviewed genetics literature and testing-provider documentation. This site does not provide medical or genetic counselling advice — always consult a healthcare professional or genetic counsellor before acting on DNA test results.
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