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Is Clubfoot Genetic?
- Heritability
- ~65%
- Inheritance
- polygenic
- Key genes
- PITX1 TBX4
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Congenital foot deformity with strong heritability (~65%); complex polygenic inheritance with PITX1 and TBX4 implicated.
How Genetic Is Clubfoot?
Clubfoot involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 65%, though no single gene determines outcome on its own.
Key genes associated with Clubfoot: PITX1 TBX4. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Clubfoot?
Family history can be informative for Clubfoot, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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