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Is Paget's Disease of Bone Genetic?
- Heritability
- ~60%
- Inheritance
- polygenic
- Key genes
- SQSTM1 TNFRSF11A
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Abnormal bone remodelling with heritability ~60%. SQSTM1 mutations are found in ~10–30% of familial cases.
How Genetic Is Paget's Disease of Bone?
Paget's Disease of Bone involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 60%, though no single gene determines outcome on its own.
Key genes associated with Paget's Disease of Bone: SQSTM1 TNFRSF11A. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Paget's Disease of Bone?
Family history can be informative for Paget's Disease of Bone, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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