This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Cystic Fibrosis Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-recessive
- Key genes
- CFTR
CircleDNA's Premium Test includes personalised reports on Cystic Fibrosis risk. See your genetic risk →
Cystic fibrosis is one of the most common severe hereditary diseases in people of Northern European descent. It is caused by mutations in the CFTR gene affecting mucus production.
How Genetic Is Cystic Fibrosis?
Cystic Fibrosis has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Cystic Fibrosis: CFTR. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Cystic Fibrosis?
Yes — family history is one of the strongest predictors of Cystic Fibrosis. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →