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Is Sickle Cell Anaemia Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-recessive
- Key genes
- HBB
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Sickle cell anaemia is caused by a specific mutation in the HBB gene altering haemoglobin structure. Carriers have one altered copy and one normal copy of the gene.
How Genetic Is Sickle Cell Anaemia?
Sickle Cell Anaemia has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Sickle Cell Anaemia: HBB. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Sickle Cell Anaemia?
Yes — family history is one of the strongest predictors of Sickle Cell Anaemia. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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