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Is Sickle Cell Anaemia Genetic?
Is Sickle Cell Anaemia hereditary? Here's what the research says about inherited risk.
- Heritability
- ~100%
- Inheritance
- autosomal-recessive
- Key genes
- HBB
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Sickle cell anaemia is caused by a specific mutation in the HBB gene altering haemoglobin structure. Carriers have one altered copy and one normal copy of the gene.
How Genetic Is Sickle Cell Anaemia?
Sickle Cell Anaemia has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Sickle Cell Anaemia: HBB. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Sickle Cell Anaemia?
Yes — family history is one of the strongest predictors of Sickle Cell Anaemia. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
Frequently Asked Questions
Is Sickle Cell Anaemia genetic?
This condition has a strong genetic basis. Studies suggest heritability of approximately 100%. Key genes involved include HBB.
Can a DNA test reveal my risk of Sickle Cell Anaemia?
Yes — DNA tests such as CircleDNA's Premium Test include reports on Sickle Cell Anaemia risk based on your genetic variants.
Does family history matter for Sickle Cell Anaemia?
Yes — family history is one of the strongest predictors of Sickle Cell Anaemia. If a first-degree relative has been diagnosed, your own risk may be significantly elevated.
Is Sickle Cell Anaemia hereditary, meaning it's passed directly from parent to child?
Sickle Cell Anaemia follows a autosomal-recessive inheritance pattern in cases with a clear genetic cause, though not every case is inherited directly from a parent — some arise from new (de novo) mutations or a combination of genetic and environmental factors.
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- MedlinePlus Genetics
- MedlinePlus Genetics — National Library of Medicine
- CDC Genomics and Precision Health
Last updated: · Reviewed by the 247GeneticCheck editorial team
Content compiled with reference to peer-reviewed genetics literature and testing-provider documentation. This site does not provide medical or genetic counselling advice — always consult a healthcare professional or genetic counsellor before acting on DNA test results.