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Is Factor V Leiden Thrombophilia Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-dominant
- Key genes
- F5
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Factor V Leiden is the most common hereditary thrombophilia in people of European descent affecting approximately 3–8%. It moderately increases the risk of deep vein thrombosis.
How Genetic Is Factor V Leiden Thrombophilia?
Factor V Leiden Thrombophilia has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Factor V Leiden Thrombophilia: F5. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Factor V Leiden Thrombophilia?
Yes — family history is one of the strongest predictors of Factor V Leiden Thrombophilia. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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