This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Hereditary Thrombophilia Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-dominant
- Key genes
- F5,F2,PROC,PROS1
CircleDNA's Premium Test includes personalised reports on Hereditary Thrombophilia risk. See your genetic risk →
Hereditary thrombophilias predispose to blood clots. Factor V Leiden and prothrombin G20210A mutations are the most common hereditary causes of venous thromboembolism.
How Genetic Is Hereditary Thrombophilia?
Hereditary Thrombophilia has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Hereditary Thrombophilia: F5,F2,PROC,PROS1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Hereditary Thrombophilia?
Yes — family history is one of the strongest predictors of Hereditary Thrombophilia. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →