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Is Paget Disease of Bone Genetic?
- Heritability
- ~40%
- Inheritance
- multifactorial
- Key genes
- SQSTM1,RANK
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Paget disease of bone causes excessive and abnormal bone remodelling. Mutations in SQSTM1 are found in 25–50% of familial cases.
How Genetic Is Paget Disease of Bone?
Genetics plays a meaningful role in Paget Disease of Bone, with heritability estimated at around 40%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Paget Disease of Bone: SQSTM1,RANK. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Paget Disease of Bone?
Family history does matter. Having close relatives with Paget Disease of Bone can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
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