This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Polymyalgia Rheumatica Genetic?
- Heritability
- ~40%
- Inheritance
- multifactorial
- Key genes
- HLA-DRB1,ICAM3,RANTES
CircleDNA's Premium Test includes personalised reports on Polymyalgia Rheumatica risk. See your genetic risk →
Polymyalgia rheumatica causes aching in muscles around the shoulders and hips. It frequently co-occurs with giant cell arteritis and shares genetic risk factors.
How Genetic Is Polymyalgia Rheumatica?
Genetics plays a meaningful role in Polymyalgia Rheumatica, with heritability estimated at around 40%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Polymyalgia Rheumatica: HLA-DRB1,ICAM3,RANTES. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: CDC Genomics
Does Family History Matter for Polymyalgia Rheumatica?
Family history does matter. Having close relatives with Polymyalgia Rheumatica can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →