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Is Retinoblastoma Genetic?
- Heritability
- ~90%
- Inheritance
- autosomal-dominant
- Key genes
- RB1
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Retinoblastoma is a childhood eye cancer. Hereditary forms are caused by germline mutations in the RB1 tumour suppressor gene and often affect both eyes.
How Genetic Is Retinoblastoma?
Retinoblastoma has a strong genetic basis. Research estimates heritability at approximately 90%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Retinoblastoma: RB1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Retinoblastoma?
Yes — family history is one of the strongest predictors of Retinoblastoma. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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