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Is Scoliosis Genetic?
- Heritability
- ~38%
- Inheritance
- multifactorial
- Key genes
- CHD7,FBN1,FBN2
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Adolescent idiopathic scoliosis has a heritable component estimated at 38%. First-degree relatives of affected individuals have an approximately 11% risk.
How Genetic Is Scoliosis?
Genetics plays a meaningful role in Scoliosis, with heritability estimated at around 38%. However, environmental factors — including diet, lifestyle, and exposure — also significantly influence risk.
Key genes associated with Scoliosis: CHD7,FBN1,FBN2. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Scoliosis?
Family history does matter. Having close relatives with Scoliosis can increase your personal risk, though it is not deterministic. Maintaining a healthy lifestyle and regular screening remain important regardless of family background.
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