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Is Hereditary Diffuse Gastric Cancer Genetic?
- Heritability
- ~80%
- Inheritance
- autosomal-dominant
- Key genes
- CDH1
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Hereditary syndrome causing diffuse-type gastric cancer with lifetime risk up to 80%. Prophylactic gastrectomy is often recommended for carriers.
How Genetic Is Hereditary Diffuse Gastric Cancer?
Hereditary Diffuse Gastric Cancer has a strong genetic basis. Research estimates heritability at approximately 80%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Hereditary Diffuse Gastric Cancer: CDH1. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Hereditary Diffuse Gastric Cancer?
Yes — family history is one of the strongest predictors of Hereditary Diffuse Gastric Cancer. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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