This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Systemic Sclerosis (Scleroderma) Genetic?
- Heritability
- ~55%
- Inheritance
- polygenic
- Key genes
- HLA-DPB1 IRF5 STAT4
CircleDNA's Premium Test covers 500+ health and ancestry reports. Explore your DNA →
Autoimmune connective tissue disease with heritability ~55%. HLA class II and interferon pathway genes are major risk factors.
How Genetic Is Systemic Sclerosis (Scleroderma)?
Systemic Sclerosis (Scleroderma) involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 55%, though no single gene determines outcome on its own.
Key genes associated with Systemic Sclerosis (Scleroderma): HLA-DPB1 IRF5 STAT4. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Systemic Sclerosis (Scleroderma)?
Family history can be informative for Systemic Sclerosis (Scleroderma), but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →