This page contains affiliate links. We may earn a commission if you purchase through them, at no extra cost to you.
Is Von Willebrand Disease Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-dominant
- Key genes
- VWF
CircleDNA's Premium Test covers 500+ health and ancestry reports. Explore your DNA →
The most common inherited bleeding disorder caused by VWF gene mutations affecting von Willebrand factor quantity or function.
How Genetic Is Von Willebrand Disease?
Von Willebrand Disease has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Von Willebrand Disease: VWF. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Von Willebrand Disease?
Yes — family history is one of the strongest predictors of Von Willebrand Disease. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
The world's most comprehensive at-home DNA test — 500+ reports covering diet, fitness, cancer risk, disease risk, and family planning.
Discover your genetic profile →