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Is Hypertrophic Cardiomyopathy Genetic?
- Heritability
- ~100%
- Inheritance
- autosomal-dominant
- Key genes
- MYH7 MYBPC3 TNNT2
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The most common inherited heart disease (~1 in 500). Mutations in sarcomere proteins cause abnormal heart muscle thickening.
How Genetic Is Hypertrophic Cardiomyopathy?
Hypertrophic Cardiomyopathy has a strong genetic basis. Research estimates heritability at approximately 100%, meaning genetic factors account for the majority of variation in whether individuals develop this condition.
Key genes associated with Hypertrophic Cardiomyopathy: MYH7 MYBPC3 TNNT2. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Hypertrophic Cardiomyopathy?
Yes — family history is one of the strongest predictors of Hypertrophic Cardiomyopathy. If a first-degree relative (parent, sibling, or child) has been diagnosed, your own risk may be significantly elevated. Discussing your family history with a healthcare provider or genetic counsellor is strongly recommended.
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