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Is Coronary Artery Disease Genetic?
- Heritability
- ~56%
- Inheritance
- polygenic
- Key genes
- 9p21 LPA PCSK9
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The leading cause of death worldwide. Heritability ~40–56%. Polygenic risk scores can identify individuals at high lifetime risk.
How Genetic Is Coronary Artery Disease?
Coronary Artery Disease involves complex interactions between multiple genes and environmental factors. Heritability estimates range up to 56%, though no single gene determines outcome on its own.
Key genes associated with Coronary Artery Disease: 9p21 LPA PCSK9. Variants in these genes have been identified through genome-wide association studies (GWAS) and clinical research as influencing susceptibility or severity.
Source: MedlinePlus Genetics
Does Family History Matter for Coronary Artery Disease?
Family history can be informative for Coronary Artery Disease, but its predictive power is limited because many genes — each with small effects — combine with environmental influences. A family history of the condition may prompt earlier or more frequent screening.
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